International project proposal funded:
Project Director: Prof. Mariana Ionita
Funding authority: NEXTGENERATION EU, Romania’s National Recovery and Resilience Plan, Ministry of Research Innovation and Digitalization
Project implementation: 36 months
Abstract: The overall objective of the REOSTEOMi project is to improve health in society by introducing unique approaches to bone regenerative medicine that not only improve & personalize implementation of existing cell / acellular bone solutions for serious complications of non-union bone fractures, but also applies knowledge acquired with this approach to devise new regenerative medicine products to treat the devastating complication of bone disease in multiple myeloma (MM). REOSTEOMi targets fabrication of bone substitutes with much improved regenerative efficiency than current treatment options used in the restoration of non-healing bone defects and the reliable delivery of novel therapeutics based on antisense oligonucleotides (ASOs) that specifically target ncRNA for restoring the osteoblastic differentiation pathway scoring osteogenesis for hBMSC and MM complications. The challenges related to delivery of novel ncRNA-based therapeutics are addressed by focusing on 2 key approaches: ASOs chemical modification / bioconjugation and DNA cages as nanocarriers. Functionalized nanostructured scaffolds fabricated by coupling 4D \ 5D bioprinting with novel biopolymer/ graphene-based inks modified / bioconjugated with ASOs will be explored for local delivery of ASOs targeting favourable biodistribution and ncRNA inhibition. Efficient ASOs delivery able to cross biological barriers and transmembrane intracellular delivery will be investigate also be employing novel, emerging self-assembling DNA nanostructures. Molecular modelling and actual design will be exploiting for the fabrication and assessment of DNA cages with precise geometries (e.g., size, flexibility and shape) fine-tuned in order to maximize their delivery potential. Given the broad range of physiological and pathological processes regulated by ncRNA, our final objective will be to investigate the potential for broader applicability of ncRNA therapeutic targets in a model of hormonally induced osteoporosis (OP).
Funding authority: NEXTGENERATION EU, Romania’s National Recovery and Resilience Plan, Ministry of Research Innovation and Digitalization
Project implementation: 36 months
Abstract: The overall objective of the REOSTEOMi project is to improve health in society by introducing unique approaches to bone regenerative medicine that not only improve & personalize implementation of existing cell / acellular bone solutions for serious complications of non-union bone fractures, but also applies knowledge acquired with this approach to devise new regenerative medicine products to treat the devastating complication of bone disease in multiple myeloma (MM). REOSTEOMi targets fabrication of bone substitutes with much improved regenerative efficiency than current treatment options used in the restoration of non-healing bone defects and the reliable delivery of novel therapeutics based on antisense oligonucleotides (ASOs) that specifically target ncRNA for restoring the osteoblastic differentiation pathway scoring osteogenesis for hBMSC and MM complications. The challenges related to delivery of novel ncRNA-based therapeutics are addressed by focusing on 2 key approaches: ASOs chemical modification / bioconjugation and DNA cages as nanocarriers. Functionalized nanostructured scaffolds fabricated by coupling 4D \ 5D bioprinting with novel biopolymer/ graphene-based inks modified / bioconjugated with ASOs will be explored for local delivery of ASOs targeting favourable biodistribution and ncRNA inhibition. Efficient ASOs delivery able to cross biological barriers and transmembrane intracellular delivery will be investigate also be employing novel, emerging self-assembling DNA nanostructures. Molecular modelling and actual design will be exploiting for the fabrication and assessment of DNA cages with precise geometries (e.g., size, flexibility and shape) fine-tuned in order to maximize their delivery potential. Given the broad range of physiological and pathological processes regulated by ncRNA, our final objective will be to investigate the potential for broader applicability of ncRNA therapeutic targets in a model of hormonally induced osteoporosis (OP).
Medical Applications of High-Power Lasers – Dr.LASER
Project Director: Prof. Horia Iovu
Funding authority: Ministry of Investments and European Projects, Romania
Project implementation: 2025 – 2029
Abstract: The project has a duration of five years and carries out several key activities, including the development of an experimental setup for laser-driven carbon ion acceleration, used in oncology treatments, and the creation of a high-sensitivity interferometric mammography system. Its main objective is the development and implementation of innovative high-power laser technologies for medical applications, with a focus on hadron therapy, advanced X-ray medical imaging, and the generation of radioisotopes for nuclear medicine.
The project is led by the National Institute for Research and Development in Physics and Nuclear Engineering ''Horia Hulube'', in collaboration with:
- Carol Davila University of Medicine and Pharmacy,
- Regional Institute of Oncology Iași,
- Oncology Institute ''Prof. Dr. Ion Chiricuță'' Cluj-Napoca,
- National University of Science and Technology Politehnica Bucharest,
- Accent Pro 2000 SRL,
- I.P. Automatic Design SRL.
POLITEHNICA Bucharest plays a crucial role in the development of X-ray medical imaging systems, specifically by:
- Creating 3D-printed medical phantoms for testing and calibrating new imaging techniques.
- Evaluating the mechanical and structural properties of these phantoms.
- Characterizing phantoms using micro-computed tomography (µCT) for validating imaging technologies.
Funding authority: Ministry of Investments and European Projects, Romania
Project implementation: 2025 – 2029
Abstract: The project has a duration of five years and carries out several key activities, including the development of an experimental setup for laser-driven carbon ion acceleration, used in oncology treatments, and the creation of a high-sensitivity interferometric mammography system. Its main objective is the development and implementation of innovative high-power laser technologies for medical applications, with a focus on hadron therapy, advanced X-ray medical imaging, and the generation of radioisotopes for nuclear medicine.
The project is led by the National Institute for Research and Development in Physics and Nuclear Engineering ''Horia Hulube'', in collaboration with:
- Carol Davila University of Medicine and Pharmacy,
- Regional Institute of Oncology Iași,
- Oncology Institute ''Prof. Dr. Ion Chiricuță'' Cluj-Napoca,
- National University of Science and Technology Politehnica Bucharest,
- Accent Pro 2000 SRL,
- I.P. Automatic Design SRL.
POLITEHNICA Bucharest plays a crucial role in the development of X-ray medical imaging systems, specifically by:
- Creating 3D-printed medical phantoms for testing and calibrating new imaging techniques.
- Evaluating the mechanical and structural properties of these phantoms.
- Characterizing phantoms using micro-computed tomography (µCT) for validating imaging technologies.
National project proposal funded:
Sustainable Polybenzoxazine-Based Materials with Self-Healing Properties for Electronic Applications (Eco-HEAL)
Project Director: Iuliana Biru
Funding authority: Academy of Scientists from Romania
Project implementation: 01.04.2024 – 30.11.2025
Abstract: The goal of the Eco-HEAL project is to develop and test demonstration models for a new product and the associated technology—namely, a simple, inexpensive, eco-friendly, and efficient material with self-healing behavior for electronic applications. The Eco-HEAL concept addresses the pressing need to develop smart materials that can endure multiple fatigue cycles, scratches, impacts, and damage while exhibiting self-healing behavior, making them suitable as recyclable substrates that could, in the long term, replace single-use electronic components.
The Eco-HEAL material will be obtained through copolymerization reactions of benzoxazine (BO)-based bio-monomers with polyethylene glycol (PEG)-based polyurethane prepolymers (PEG-PU), using eco-friendly and low-cost raw materials. The material will have repeatable self-healing capacity due to their supramolecular interactions based on hydrogen bonding. The self-healing poly(BO-co-U) materials will be produced using a scalable technology that utilizes sesame extract derivatives as natural substitutes for toxic petroleum-derived phenolic compounds to create BO monomers that can react with non-toxic PEGylated PU prepolymers. The poly(BO-co-U) matrices with self-healing properties will be achieved by inducing weak but high-density hydrogen bond networks formed during the copolymerization process, which will be responsible for excellent mechanical strength and self-repair.
Funding authority: Academy of Scientists from Romania
Project implementation: 01.04.2024 – 30.11.2025
Abstract: The goal of the Eco-HEAL project is to develop and test demonstration models for a new product and the associated technology—namely, a simple, inexpensive, eco-friendly, and efficient material with self-healing behavior for electronic applications. The Eco-HEAL concept addresses the pressing need to develop smart materials that can endure multiple fatigue cycles, scratches, impacts, and damage while exhibiting self-healing behavior, making them suitable as recyclable substrates that could, in the long term, replace single-use electronic components.
The Eco-HEAL material will be obtained through copolymerization reactions of benzoxazine (BO)-based bio-monomers with polyethylene glycol (PEG)-based polyurethane prepolymers (PEG-PU), using eco-friendly and low-cost raw materials. The material will have repeatable self-healing capacity due to their supramolecular interactions based on hydrogen bonding. The self-healing poly(BO-co-U) materials will be produced using a scalable technology that utilizes sesame extract derivatives as natural substitutes for toxic petroleum-derived phenolic compounds to create BO monomers that can react with non-toxic PEGylated PU prepolymers. The poly(BO-co-U) matrices with self-healing properties will be achieved by inducing weak but high-density hydrogen bond networks formed during the copolymerization process, which will be responsible for excellent mechanical strength and self-repair.
Analysis of correlations between the histopathological type of differentiated Thyroid Cancer (papillary and follicular) and radioiodine therapy
Project Director: Irina Oana Lixandru Petre
Funding authority: Academy of Scientists from Romania
Project implementation: 01.04.2024 – 30.11.2025
Abstract: The project has as its principal objective creating interdisciplinary links and knowledge transfer between the parties involved in the project [eBio-hub team (eBio-hub CAMPUS), HPC data center (PRECIS, Faculty of Automation and Computers) - National University of Science and Technology Politehnica Bucharest, Romanian Academy of Scientists and National Institute of Endocrinology ''C.I. Parhon''] for the joint development of artificial intelligence-based solutions for clinical and medical applications.
Using statistical and analytical analysis based on real thyroid cancer data, we will be able to develop treatment models for a more favorable response to this disease.
Funding authority: Academy of Scientists from Romania
Project implementation: 01.04.2024 – 30.11.2025
Abstract: The project has as its principal objective creating interdisciplinary links and knowledge transfer between the parties involved in the project [eBio-hub team (eBio-hub CAMPUS), HPC data center (PRECIS, Faculty of Automation and Computers) - National University of Science and Technology Politehnica Bucharest, Romanian Academy of Scientists and National Institute of Endocrinology ''C.I. Parhon''] for the joint development of artificial intelligence-based solutions for clinical and medical applications.
Using statistical and analytical analysis based on real thyroid cancer data, we will be able to develop treatment models for a more favorable response to this disease.
Novel smart hydrogels based on biopolymers and graphene oxide for photothermal therapy (Co.no.23/09.10.2023)
Project Director: Dr. Iuliana Biru (iuliana.biru[at]upb.ro)
Funding authority: National – GNAC
Project implementation: 09.10.2023 - 31.12.2024
Abstract: The present project focuses on the development of new hydrogels for synergistic anticancer treatment by combining the photothermal effect (PTT) and chemotherapy (CT), targeting prostate cancer. Complex nanoarchitectures based on reduced graphene oxide (rGO) modified with bovine serum albumin (BSA) will be designed. The rGO structure will be involved as a thermal ablation agent, and BSA will ensure the biocompatibility and hydrophilic-hydrophobic balance suitable for drug transport. A combination of drugs (docetaxel (DTX) and Curcumin (C)) will be used against prostate cancer. The presence of a second therapeutic agent, curcumin, with photosensitizing properties, will increase the photothermal efficiency induced by the rGO structure. The idea of the project highlights key points for future scientific studies and will allow further investigations in the case of the effectiveness of rGO/protein nanoplatforms for PTT-CT to understand the mechanism of action at the cellular level. In addition, the project will address innovative methods to avoid the classic intravenous administration of drugs with low targeting efficiency of tumor tissues by introducing synthesized nanoparticles into an injectable hydrogel that will be subjected to 3D bioprinting for the development of a personalized therapy.
Funding authority: National – GNAC
Project implementation: 09.10.2023 - 31.12.2024
Abstract: The present project focuses on the development of new hydrogels for synergistic anticancer treatment by combining the photothermal effect (PTT) and chemotherapy (CT), targeting prostate cancer. Complex nanoarchitectures based on reduced graphene oxide (rGO) modified with bovine serum albumin (BSA) will be designed. The rGO structure will be involved as a thermal ablation agent, and BSA will ensure the biocompatibility and hydrophilic-hydrophobic balance suitable for drug transport. A combination of drugs (docetaxel (DTX) and Curcumin (C)) will be used against prostate cancer. The presence of a second therapeutic agent, curcumin, with photosensitizing properties, will increase the photothermal efficiency induced by the rGO structure. The idea of the project highlights key points for future scientific studies and will allow further investigations in the case of the effectiveness of rGO/protein nanoplatforms for PTT-CT to understand the mechanism of action at the cellular level. In addition, the project will address innovative methods to avoid the classic intravenous administration of drugs with low targeting efficiency of tumor tissues by introducing synthesized nanoparticles into an injectable hydrogel that will be subjected to 3D bioprinting for the development of a personalized therapy.
Project Director: Prof. Horia IOVU (horia.iovu[at]upb.ro)
Funding authority: The Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI)
Project implementation: 01.11.2023 – 31.12.2027
Abstract: The current project aims to develop three important platform technologies, which will support the eBio-hub Research Centre activity. First, it targets to develop a platform technology to fabricate nanoparticles as nanocarriers using surface acoustic waves (SAW) generated in a microfluidic channel. A second platform technology is targeting a “tool” for the previously designed nanocarriers- microneedles patches developed in a personalized way using SAW and 3D printing. The third platform technology is targeting 3D skin models for drug testing. We believe that the developing platform technologies will be the “fundamental pillars” for the maturing eBio-hub research centre.
Funding authority: The Executive Agency for Higher Education, Research, Development and Innovation Funding (UEFISCDI)
Project implementation: 01.11.2023 – 31.12.2027
Abstract: The current project aims to develop three important platform technologies, which will support the eBio-hub Research Centre activity. First, it targets to develop a platform technology to fabricate nanoparticles as nanocarriers using surface acoustic waves (SAW) generated in a microfluidic channel. A second platform technology is targeting a “tool” for the previously designed nanocarriers- microneedles patches developed in a personalized way using SAW and 3D printing. The third platform technology is targeting 3D skin models for drug testing. We believe that the developing platform technologies will be the “fundamental pillars” for the maturing eBio-hub research centre.
